Evidence of Test Benefitsfishnyc222023-06-01T10:07:30-04:00
Medical Journal Articles
DPYD Testing: A Guide for Oncologists for Discussing with Patients.
“All You Need to Know About DPYD Testing for Patients Treated with Fluorouracil and Capecitabine: A Practitioner-Friendly Guide” (2020).
This paper provides “a single guide for health care professionals to make an evidence-based decision about DPYD testing for patients with cancer” … and “the essential knowledge base for oncologists to have an informed discussion with their patients about the genetic testing for DPYD. This document assists practitioners in quickly evaluating whether, when, where, and how to order a DPYD genetic test”.
“DPYD Testing: Time to Put Patient Safety First”, 2023.
“We recommend that pretreatment DPYD variant testing should be incorporated immediately into the standard of care for fluoropyrimidine regimens. Since fluoropyrimidine pharmacokinetic exposure is higher in reduced-function DPYD variant carriers, starting at a reduced dose and titrating upward to avoid undue toxicity should be adequate to maximize benefit while reducing risk in patients carrying heterozygous genotypes.”
Clinical Relevance of DPYD Variants… as Predictors of Severe Fluoropyrimidine-hToxicity: A Systematic Review and Meta-Analysis of Individual Patient Data.
This 2015 Meulindijks study found: “Clinical validity has now been established for four DPYD variants… and upfront screening for these mutations with dose adaptation in variant allele carriers is advised to improve patient safety…”
Two medical professionals discuss the Pros and Cons of universal DPYD pre-screening. Dr. Dan Hertz, PharmD at the University of Michigan presents the benefits of testing while Dr. Suneel D. Kamath, MD at the Cleveland Clinic discusses the challenges with clinical implementation of DPYD testing. Recording date is January 2022.
Dr. Julien Taieb-Hegp’s presentation entitled: “Should DPD Deficiency Be Searched (sic) Before Starting 5FU?” at the World Gastrointestinal Conference of the European Society of Medical Oncologists in 2020.